In DM group mice, renal glomerulus area was magnified, mesenterium basilaris substantia was increased, urinary cast lumina was enlarged, its vessel wall was thinner, GBM was thickening and obvious protein casts were observed compared with those of C group. DM组小鼠肾小球面积较C组增大,系膜基质增加、肾小管管腔扩大、管壁变薄、肾小球基底膜(GBM)增厚、蛋白管型明显。